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Основы социологии          Автор Azhar S.          Издательство Книга по Требованию

Trip through the Pharmacology of hot- and cold sensing TRP Ion Channels. A hope for better painkiller and anti-inflammatory drugs
132 стр. мягкая обложка
978-3-6392-4933-0

автор:Azhar S.
издательство: Книга по Требованию
год:2010
цена:2414 руб
- нет в наличии

The mammalian nervous system is capable of performing its sensory function because of the presence of thermo-TRPs at the peripheral free nerve endings and in keratinocytes. These are TRPM8, TRPV1-V4 and TRPA1. The warmth of the kiss of a beloved and the chilliness of cold winter winds are well known phenomenon liked or alternatively disliked by humans. Thermo-TRPs is a subgroup of the TRP-super family of cation channels and consists of six members of diverse channel forming proteins. TRPA1 senses cold temperature below 15 °C, TRPM8 senses cool temperatures ( 25 °C), TRPV3 and TRPV4 sense normal body warmth (28 °C They are grouped together because one of their functions is thermal sensation. Both are nothing but temperature sensations at two different levels. Mammals sense ambient temperature through primary afferent sensory neurons of the dorsal root ganglion and trigeminal ganglion. These cells convey thermal information from peripheral tissues to the spinal cord and brain where the signals are interpreted. This results in appropriate cognitive and reflexive responses.

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Английский язык с Шерлоком Холмсом. Первый сборник рассказов (ASCII-IPA)

Holmes shot the slide across the front of his lantern and left us in pitch darkness such an absolute darkness as I have never before experienced. The smell of hot metal remained to assure us that the light was still there, ready to flash out at a moment's notice. To me, with my nerves worked up to a pitch of expectancy, there was something depressing and subduing in the sudden gloom, and in the cold dank air of the vault. "They have but one retreat," whispered Holmes. "That is back through the house into Saxe-Coburg Square. I hope that you have done what I asked you, Jones?" "I have an inspector and two officers waiting at the front door (инспектор и два офицера ждут у парадного входа)." "Then we have stopped all the holes (тогда мы заткнули все дыры). And now we must be silent and wait (а теперь мы должны быть тихими = молчать и ждать)." holes [h@ulz], silent ['saIl@nt] What a time it seemed (что за время это казалось = как медленно тянулось время)! From comparing notes afterwards (из обмена мнениями позже) it was but an hour and a quarter (/было ясно/ что прошел только час с четвертью), yet it appeared to me that the night must have almost gone (тем не менее, мне казалось, что ночь, должно быть, уже почти прошла), and the dawn be breaking above us (и наверху: «над нами» рассветает) ...

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