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Другие общетехнические дисциплины          Автор Marielle Y.          Издательство Книга по Требованию

Regulation of the exchange activity of Dbl-family proteins. Auto-inhibition, intermolecular interactions and phosphorylation in the regulation of Dbl-family proteins
108 стр. мягкая обложка
978-3-6391-6150-2

автор:Marielle Y.
издательство: Книга по Требованию
год:2009
цена:1979 руб
- нет в наличии

The exchange activities of many Dbl-proteins are regulated by phosphorylation or constitutively activated by truncations preceding their DH domains. The current literature regarding the activation and inhibition of the exchange activity of the human Dbl-family proteins is reviewed here, with a focus on general mechanisms of regulation common to many of these proteins. Dbl-related oncoproteins are guanine nucleotide exchange factors (GEFs) specific for Rho-family GTPases and typically possess tandem Dbl (DH) and pleckstrin homology (PH) domains that act in concert to catalyze exchange. However, exact mechanisms of regulation remain poorly understood.

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