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Другие общетехнические дисциплины          Автор Marielle Y.          Издательство Книга по Требованию

Regulation of the exchange activity of Dbl-family proteins. Auto-inhibition, intermolecular interactions and phosphorylation in the regulation of Dbl-family proteins
108 стр. мягкая обложка

автор:Marielle Y.
издательство: Книга по Требованию
цена:1979 руб
- нет в наличии

The exchange activities of many Dbl-proteins are regulated by phosphorylation or constitutively activated by truncations preceding their DH domains. The current literature regarding the activation and inhibition of the exchange activity of the human Dbl-family proteins is reviewed here, with a focus on general mechanisms of regulation common to many of these proteins. Dbl-related oncoproteins are guanine nucleotide exchange factors (GEFs) specific for Rho-family GTPases and typically possess tandem Dbl (DH) and pleckstrin homology (PH) domains that act in concert to catalyze exchange. However, exact mechanisms of regulation remain poorly understood.

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Agile Software Development

This is the longest time that can be needed for the project. With the most careful management, the project manager will get the longest elapsed time at the minimum labor cost. For projects on which reducing elapsed time is a top priority; this is a bad tradeoff. The second problem is that surprises usually do crop up during the project. When one does, it causes unexpectedly revision of the requirements or design, raising the development cost. In the end, the project manager minimizes neither the labor cost nor the development time. The third problem is absence of feedback from the downstream activities to the upstream activities. In rare instances, the people doing the upstream activity can produce high-quality results without feedback from the downstream team. On most projects, though, the people creating the requirements need to see a running version of what they ordered, so they can correct and finalize their requests. Usually, after seeing the system in action, they change their requests, which forces changes in the design, coding, testing, and so on ...

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