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Художественная литератураДетская литератураШкола. ПедагогикаДом. Быт. Досуг. ТуризмКультура и общество
Бизнес. Экономика. ПравоНаука. Техника.ТранспортЯзыки. ФилологияМедицина. ЗдоровьеРазное

Информационные технологии в экономике          Автор Catherine L.W.C.          Издательство Книга по Требованию

Quantifying, interpreting and explaining heterogeneity over centers in multicenter cancer clinical trials Assessing heterogeneity in clinical trials using the frailty model.
188 стр. мягкая обложка
978-3-6392-1334-8

автор:Catherine L.W.C.
издательство: Книга по Требованию
год:2009
цена:2782 руб
Количество

Various approaches are discussed to fit such a frailty model, and a Bayesian approach based on the Laplace approximation is detailled. For example, it may be interesting to investigate heterogeneity in outcome and in treatment effect over centers. Considering a frailty model including a random center effect and a random treatment by center interaction term, we demonstrate how to quantify this heterogeneity, to interpret it based on medically relevant quantities, and to identify center and patient specific factors explaining it. Based on the same idea, we also propose to study heterogeneity in prognostic index effect over centers, and to use this information to get a new insight in the validation of prognostic indices. While the primary objective of multicenter clinical trials is to compare treatments for a specific disease, they also contain a lot of relevant additional information. We illustrate this research using data from an EORTC multicenter clinical trial for breast cancer and from a pooled database of seven EORTC clinical trials in bladder cancer patients.


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Теории личности

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