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Физическая химия          Автор Anna A.          Издательство Книга по Требованию

Molecular models of HIV-1 targets/drugs. Implications in resistance and rational design of novel antiviral agents
144 стр. мягкая обложка
978-3-6391-8326-9

автор:Anna A.
издательство: Книга по Требованию
год:2009
цена:2401 руб
- нет в наличии

Understanding the genetic basis of resistance and cross-resistance is essential for optimizing the use of existing drugs and for designing new antiviral agents. Nevertheless, when antiretroviral therapy fails, new viral variants emerge, thus allowing HIV-1 to become resistant to drugs by accumulating mutations, either alone or in multiple patterns. Three HIV-1 macromolecular targets crucial for viral fitness and replication have been analyzed: the reverse transcriptase, the protease and the envelope glycoprotein gp41. This book, therefore, provides new computational approaches aimed to rationalize the effects of known resistance- inducing mutations and to discover novel selective anti-HIV resistance-evading drugs. The combined use of anti- AIDS drugs has significantly improved the clinical management of HIV-1 infection. In last years relevant progress in the development and clinical use of drugs for treating HIV-1 infection has been made. The medicinal chemist can use these approaches to predict the effects of certain HIV-1 PR relevant mutations in presence of novel inhibitors.

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