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Физическая химия          Автор Frederic P.          Издательство Книга по Требованию

Folinic Acid
96 стр. мягкая обложка
978-6-1325-8540-0

автор:Frederic P.
издательство: Книга по Требованию
год:2010
цена:1393 руб
- нет в наличии

Folinic acid (INN) or leucovorin (USAN), generally administered as calcium or sodium folinate (or leucovorin calcium/sodium), is an adjuvant used in cancer chemotherapy involving the drug methotrexate. They are configurated S at the remaining asymmetric carbon atom (see below). It is also used in synergistic combination with the chemotherapy agent 5- fluorouracil. Folinic acid should be distinguished from folic acid. High Quality Content by WIKIPEDIA articles! Levofolinic acid and its salts are the enantiopure drugs.

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Нечего и говорить, что этих признаков было недостаточно во многих случаях, чтобы высказаться, принадлежит данное тело к К. или нет. До Лавуазье, состав К. был почти не исследован. Для объяснения их свойств существовали различные взгляды. Прежде всего, предполагали, что все К. должны заключать в своем составе нечто общее, которое и обуславливает их кислотную натуру. Это так называемая первичная К. acidum primigenium, acide universеle, Ursaure. Одни из ученых, напр. Becher, предполагали, что эта первичная К. в наиболее чистом виде находится в соляной К.; другие, напр. Stahl - в серной. Stahl предполагал, что серная К., соединяясь с флогистоном, дает сернистую К., что она превращается в азотную К. при помощи брожения (гниения) и соединения с флогистоном, что она так же дает соляную К. Относительно состава первичной К., он полагал, что она образована из элементов "воды" и "земли". Оригинальных взглядов на К. держался Лемери. Он принимал, что частицы К. являются в виде иголочек вечно движущихся; для разных К. эти иголочки различной длины и тодщины; растворение какого-нибудь тела состоит в проникновении его этими игольчатыми частицами ...

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