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Органическая химия          Автор Hanns S.          Издательство Книга по Требованию

Essential proteins of parasitic nematodes:. Proteomic analysis of excretory/secretory proteins from parasitic and free-living stages of Strongyloides ratti
204 стр. мягкая обложка
978-3-8381-1024-0

автор:Hanns S.
издательство: Книга по Требованию
год:2009
цена:3985 руб
- нет в наличии

For research purposes the closely related parasitic nematode S. ratti can be used to study stage development, life cycle and parasitism. The high genetic similarity then allows to draw parallels between the human parasite and other Strongylid nematodes. Assuming that the protein patterns of larval and adult stages show differences, the results of the mass spectrometric analysis were compared. By choosing this approach it was possible to identify 1,081 proteins of S. ratti. Many of the proteins were also shown to be present as homologues in the culture supernatants and extracts of other parasitic nematodes and some proteins seem to be Strongyloides- specific. This work presents the establishment of the S. ratti life cycle at the BNI-Hamburg and the proteomic analysis of E/S and extract proteins from various developmental stages at the Proteomics Center, Boston. Strongyloidiasis is one of the important intestinal nematode diseases and it is estimated that worldwide between 50-200 million people are infected by the human pathogen Strongyloides stercoralis.

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