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Органическая химия          Автор Hanns S.          Издательство Книга по Требованию

Essential proteins of parasitic nematodes:. Proteomic analysis of excretory/secretory proteins from parasitic and free-living stages of Strongyloides ratti
204 стр. мягкая обложка

автор:Hanns S.
издательство: Книга по Требованию
цена:3985 руб
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For research purposes the closely related parasitic nematode S. ratti can be used to study stage development, life cycle and parasitism. The high genetic similarity then allows to draw parallels between the human parasite and other Strongylid nematodes. Assuming that the protein patterns of larval and adult stages show differences, the results of the mass spectrometric analysis were compared. By choosing this approach it was possible to identify 1,081 proteins of S. ratti. Many of the proteins were also shown to be present as homologues in the culture supernatants and extracts of other parasitic nematodes and some proteins seem to be Strongyloides- specific. This work presents the establishment of the S. ratti life cycle at the BNI-Hamburg and the proteomic analysis of E/S and extract proteins from various developmental stages at the Proteomics Center, Boston. Strongyloidiasis is one of the important intestinal nematode diseases and it is estimated that worldwide between 50-200 million people are infected by the human pathogen Strongyloides stercoralis.

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The Language of the Genes

When the virus strikes it uses the plant's machinery to make copies of itself. If parts of its own structure are already there, the mechanism is disrupted and the attack fails. Virus resistance has been introduced into rice and peppers, and genes that resist parasitic worms into potatoes and bananas, although none has yet been used on farms. We grow plants because they make useful things; food, for example. As most plants lack certain amino acids it is hard to stay healthy on a strict vegetarian diet. Much could be done by moving the right genes in and many hopes are pinned on 'golden rice', which has within it a new gene for vitamin A (whose deficiency causes half a million third-world children to go blind each year). Some foodstuffs, such as broccoli, contain anti-cancer substances and the DNA responsible might be introduced to other species. Plants could even be used as biological factories, with the prospect of using potatoes to make antibodies or other blood proteins. Already, rice can make a human protein used to treat cystic fibrosis and other lung diseases ...

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