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Другие общетехнические дисциплины          Автор Christian L.          Издательство Книга по Требованию

Energy Landscapes of Protein Folding: Structure and Function of Intermediate States of Ankyrin Repeat Proteins From Structure to Function.
196 стр. мягкая обложка

автор:Christian L.
издательство: Книга по Требованию
цена:3619 руб
- нет в наличии

To function, they need a defined three dimensional structure. To understand the process by which a polypeptide chain folds into its three-dimensional structure (the so-called protein folding reaction) is an essential element in structural biology. This work mainly focusses on the structural and functional characterization of partially folded intermediate states, which can accumulate during the folding process. All the information necessary for a protein to achieve this conformation is encoded in its amino acid sequence. Proteins are the vital molecules in living cells and important targets for pharmaceutical and biotechnological applications. Ankyrin Repeat proteins were choosen as model proteins, since their architectural simplicity allows the dissection of energetics to different structural elements.

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Future Shock

Organizations in this sector are precisely the ones that rely most heavily on transient teams and task forces. Clearly, there is nothing new about the idea of assembling a group to work toward the solution of a specific problem, then dismantling it when the task is completed. What is new is the frequency with which organizations must resort to such temporary arrangements. The seemingly permanent structures of many large organizations, often because they resist change, are now heavily infiltrated with these transient cells. On the surface, the rise of temporary organization may seem insignificant. Yet this mode of operation plays havoc with the traditional conception of organization as consisting of more or less permanent structures. Throw-away organizations, ad hoc teams or committees, do not necessarily replace permanent functional structures, but they change them beyond recognition, draining them of both people and power. Today while functional divisions continue to exist, more and more project teams, task forces and similar organizational structures spring up in their midst, then disappear ...

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