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Органическая химия          Автор Jonathan R.          Издательство Книга по Требованию

Computational Methods for Fragment Spectrum Interpretation. Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications
56 стр. мягкая обложка

автор:Jonathan R.
издательство: Книга по Требованию
цена:2006 руб
- нет в наличии

However, interpretation of tandem MS spectra including fragment ions with PTMs from high-throughput experiments is a complex challenge. Information on both precursor and fragment ion level is utilized and an arbitrary number of PTMs is considered. Mass spectrometry (MS) can shed light on the characteristics of PTMs to gain insight into the mechanisms of numerous diseases including cancer. Post-translational modifications (PTMs) are of critical importance for a vast range of cellular processes such as growth control and signal transduction. A robust statistical noise intensity model is developed to compensate for low spectrum quality. Finally, the algorithm is successfully applied on the fragment spectra in the PRIDE proteomics data repository to render it suitable for statistical machine learning investigations. In this book, an efficient algorithm for the computational interpretation of tandem MS spectra including fragment ions with PTMs is described. The high number and diversity of known PTMs as well as suboptimal quality of spectra compromise the identification of PTMs in MS experiments.

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Fedora™ Unleashed, 2008 edition

Select any process and kill it with End Process. You can change the nice value of the processes by selecting Edit, Change Priority. The View selection from the menu bar also provides a memory map. In the Resources tab, you can view a moving graph representing CPU and memory use (see Figure 12.4). FIGURE 12.4 The Graph view of the System Monitor. It shows CPU use, memory/swap use, and disk use. To get this view, select the Resources tab. Finally, you can see the status of your file system and storage devices by clicking the File Systems tab shown in Figure 12.5. FIGURE 12.5 Keep a close eye on your free disk space. KDE Process- and System-Monitoring Tools KDE provides several process- and system-monitoring clients. Integrate the KDE graphical clients into the desktop taskbar by right-clicking the taskbar and following the menus. These KDE monitoring clients include the following: ► kdf — A graphical interface to your system's file system table that displays free disk space and enables you to mount and unmount file systems with a pointing device ► ksysguard — Another panel applet that provides CPU load and memory use information in animated graphs Reference ►  — Home page of the AND auto-nice daemon, which can be used to prioritize and reschedule processes automatically. ►  — Home page for various projects offering scheduling utilities for real-time scheduling. ►  — A discussion of the FreeType bytecode interpreter patents. ►  — Home page for the Ethereal client. ►  — The home page for the Virtual Network Computing remote desktop software, available for a variety of platforms, including Fedora Core Linux ...

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