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Медико-биологические дисциплины          Автор Joseph F.          Издательство Книга по Требованию

Aberrant Cell Biology in Cystic Fibrosis Cells. Cell Biological Basis for Aberrant Function in Infection and Inflammation in Cystic Fibrosis Respiratory Epithelial Cells
132 стр. мягкая обложка

автор:Joseph F.
издательство: Книга по Требованию
цена:2383 руб
- нет в наличии

The first aspect covered involves the basis for previously described hyperacidification of organelles in CF cells, and how this phenomenon can be pharmacologically corrected. The third aspect involves the discovery of attenuated polymeric IgA transcytosis in CF cells, which may contribute to excessive colonization of P. aeruginosa. Future directions addressing these aspects of the cell biology of CF are outlined. The second aspect focuses on the excessive production of a molecule named Sialyl-Lewis X (Slx) in CF cells. This book describes a novel cell biological basis contributing to aberrant innate immunity and inflammation in the cystic fibrosis (CF) respiratory tract. Slx acts as a receptor for neutrophils which cause excessive damage in the CF bronchial epithelia.

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The Language of the Genes

All this make the process more and more ambiguous. Decisions based on appraisals of inborn quality;uc not new but now, for the first time, may be accurate. Should damaged genes be allowed to pass to the next generation, or should the human race attempt to enhance its quality in some way? There are each year, worldwide, about ninety million births and sixty million induced abortions. Britain alone in 1998 had a hundred and eighty thousand abortions, only two thousand of which were on grounds of abnormality. Many more pregnancies end without the woman knowing of her condition, often because the foetus has a severe genetic defect. Even more eggs are lost. A baby girl has a million or so in her ovaries. Three quarters disappear before puberty, and at the age of twenty five she loses, on average, forty or so a day while producing only one a month. The waste of sperm is even more prodigious and, for either sex, many of the sex cells are doomed because of their biological weakness. Genetic selection is a natural part of reproduction ...

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